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Global Science Lead Enzyme Therapeutics (Rx)

Global Science Lead Enzyme Therapeutics (Rx)

Position Snapshot


Location: Vers-chez-les-Blancs, Switzerland 
Company: Nestlé Health Science
Permanent contract, Full time 
Average travel expectations: 20%/year approx.
 

This is a permanent opportunity and here at Nestlé many of our colleagues work flexibly and in many different ways, different core hours and remote working. Please talk to us during the recruitment process about what flexibility could look like for you.

This position can also be based in UK or US 

 

Position summary


Reporting to the Global Head of Strategic Research Collaborations, you will be responsible for research and preclinical/non-clinical studies conducted on behalf of NHSc with external partners and/or Contract Research Organizations (CROs).

 

You will also represent research represent research, preclinical and early drug development on project teams and/or sub-teams to support the development of clinical drug candidates in the field of therapeutic enzymes in gastro-intestinal and other disease areas.

 

A day in the life of a Global Science Lead Enzyme Therapeutics (Rx)

 

•    Design and oversee IND- and CTA- enabling preclinical programs: including target identification and validation, relevant disease models for preclinical proof-of concept, PK/PD and dose range finding studies, safety, and drug non-clinical developments, such as CMC to proceed to IND and enable phase 1 human studies 
•    Initiate advance key development programs, including preclinical study planning and budgeting, execution oversight and reporting to steering committee(s)
•    Secure the differentiation of early & mid stage compounds including identification of new indications and successful generation of new IP
•    Target identification and engagement markers
•    Design proof of concept studies in relevant animal disease models                
•    Conduct scientific and technical review for nonclinical studies performed with external collaborators or CROs. 
•    Review and finalize nonclinical study reports (both non-GLP and GLP studies). 
•    Together pharmacology/toxicology and regulatory project lead engage with regulatory agencies to resolve nonclinical issues            
•    Implementation of scientific discoveries, breakthrough technology platforms, as well as early to mid-terms target assets in the allergy and immune-related gastro-intestinal (GI) therapeutics (aligned with NHSc Rx strategy and product portfolio)"                
•     Act as Preclinical Development representative on project teams and/or sub teams for clinical development of novel allergy/immunology therapeutics (Rx)    

            
What will make you successful


•    Ph.D. or MD/Ph.D in Biochemistry or Pharmacology with specialization in Protein chemistry/Enzymology (enzyme expert)
•    Experience in drug discovery and PK/PD assessment and modeling.
•    Early drug development experience, with minimum 5 to 8 years working in biotech/pharma companies
•    Experience in coordination, organization, analysis, and documentation of nonclinical studies 
•    Experience in gastro-intestinal and metabolism related diseases where dysfunctional enzymes play a key role in driving pathology
•    Experience managing research programs involving external partners. 
•    Exposure to business development / acquisition a plus


Nestlé Health Science is a leader in the science of nutrition, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands.  Headquartered in Switzerland, we have more than 11,000 employees around the world, with products available in more than 140 countries. 

 

Aimmune Therapeutics is the pharmaceutical unit of Nestle Health Science (NHSc), with a focus on the advancement of treatments for food allergy, GI disorders, and other food-mediated diseases. We are continuing to build a world-class R&D organization with a strong development infrastructure to support programs in gastroenterology, food allergies and other metabolic & inflammatory diseases. The R&D function within Aimmune Therapeutics drives development activities related to the pharmaceutical pipeline. 

 

We aim to hire friendly, respectful, inspiring people who care about the people’s lives that we touch every single day. Be a force for good. Join Nestlé and visit us on www.nestle.com.

Position Snapshot


Location: Vers-chez-les-Blancs, Switzerland 
Company: Nestlé Health Science
Permanent contract, Full time 
Average travel expectations: 20%/year approx.
 

This is a permanent opportunity and here at Nestlé many of our colleagues work flexibly and in many different ways, different core hours and remote working. Please talk to us during the recruitment process about what flexibility could look like for you.

This position can also be based in UK or US 

 

Position summary


Reporting to the Global Head of Strategic Research Collaborations, you will be responsible for research and preclinical/non-clinical studies conducted on behalf of NHSc with external partners and/or Contract Research Organizations (CROs).

 

You will also represent research represent research, preclinical and early drug development on project teams and/or sub-teams to support the development of clinical drug candidates in the field of therapeutic enzymes in gastro-intestinal and other disease areas.

 

A day in the life of a Global Science Lead Enzyme Therapeutics (Rx)

 

•    Design and oversee IND- and CTA- enabling preclinical programs: including target identification and validation, relevant disease models for preclinical proof-of concept, PK/PD and dose range finding studies, safety, and drug non-clinical developments, such as CMC to proceed to IND and enable phase 1 human studies 
•    Initiate advance key development programs, including preclinical study planning and budgeting, execution oversight and reporting to steering committee(s)
•    Secure the differentiation of early & mid stage compounds including identification of new indications and successful generation of new IP
•    Target identification and engagement markers
•    Design proof of concept studies in relevant animal disease models                
•    Conduct scientific and technical review for nonclinical studies performed with external collaborators or CROs. 
•    Review and finalize nonclinical study reports (both non-GLP and GLP studies). 
•    Together pharmacology/toxicology and regulatory project lead engage with regulatory agencies to resolve nonclinical issues            
•    Implementation of scientific discoveries, breakthrough technology platforms, as well as early to mid-terms target assets in the allergy and immune-related gastro-intestinal (GI) therapeutics (aligned with NHSc Rx strategy and product portfolio)"                
•     Act as Preclinical Development representative on project teams and/or sub teams for clinical development of novel allergy/immunology therapeutics (Rx)    

            
What will make you successful


•    Ph.D. or MD/Ph.D in Biochemistry or Pharmacology with specialization in Protein chemistry/Enzymology (enzyme expert)
•    Experience in drug discovery and PK/PD assessment and modeling.
•    Early drug development experience, with minimum 5 to 8 years working in biotech/pharma companies
•    Experience in coordination, organization, analysis, and documentation of nonclinical studies 
•    Experience in gastro-intestinal and metabolism related diseases where dysfunctional enzymes play a key role in driving pathology
•    Experience managing research programs involving external partners. 
•    Exposure to business development / acquisition a plus


Nestlé Health Science is a leader in the science of nutrition, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands.  Headquartered in Switzerland, we have more than 11,000 employees around the world, with products available in more than 140 countries. 

 

Aimmune Therapeutics is the pharmaceutical unit of Nestle Health Science (NHSc), with a focus on the advancement of treatments for food allergy, GI disorders, and other food-mediated diseases. We are continuing to build a world-class R&D organization with a strong development infrastructure to support programs in gastroenterology, food allergies and other metabolic & inflammatory diseases. The R&D function within Aimmune Therapeutics drives development activities related to the pharmaceutical pipeline. 

 

We aim to hire friendly, respectful, inspiring people who care about the people’s lives that we touch every single day. Be a force for good. Join Nestlé and visit us on www.nestle.com.

Lausanne, CH

Lausanne, CH

Apply now »